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Drug ReportsPolymyxin b
Polymyxin b
Aerosporin, Casporyn, Chloromyxin, Cortisporin, Lanabiotic, Lumi-sporyn, Maxitrol, Mycitracin, Neo-polycin, Neosporin, Ocumycin, Ophthocort, Otobiotic, Poly-pred, Poly-rx, Polysporin, Polytrim, Pyocidin, Statrol (polymyxin b) is a protein pharmaceutical. Polymyxin b was first approved as Bacitracin-neomycin-polymyxin w/ hydrocortisone acetate on 1982-01-01. It is used to treat bacteremia, bacterial eye infections, bacterial infections, bacterial meningitis, and escherichia coli infections amongst others in the USA. It is known to target P2X purinoceptor 7.
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Drug
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Financial
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1M
3M
6M
YTD
1Y
2Y
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EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Polymyxin b (discontinued: Aerosporin, Polymyxin b)
Combinations
Bacitracin polymyxin b, Bacitracin-neomycin-polymyxin w/ hydrocortisone, Casporyn, Dexasporin, Lumi-sporyn, Maxitrol, Neomycin polymyxin b, Neomycin polymyxin b sulfates bacitracin, Neomycin polymyxin b sulfates dexamethasone, Neomycin polymyxin b sulfates gramicidin, Neomycin polymyxin b sulfates hydrocortisone, Neomycin polymyxin b sulfates, bacitracin hydrocortisone, Neosporin, Neosporin g.u. irrigant, Oticair, Trimethoprim polymyxin b (discontinued: Bacitracin polymyxin b, Bacitracin-neomycin-polymyxin, Bacitracin-neomycin-polymyxin w/ hydrocortisone, Chloromyxin, Cortisporin, Dexacidin, Lanabiotic, Mycitracin, Neo-polycin, Neomycin polymyxin b sulfates bacitracin, Neomycin polymyxin b sulfates dexamethasone, Neomycin polymyxin b sulfates gramicidin, Neomycin polymyxin b sulfates hydrocortisone, Neomycin polymyxin b sulfates, bacitracin hydrocortisone, Neosporin, Ophthocort, Otobione, Otobiotic, Otocort, Pediotic, Poly-pred, Polysporin, Polytrim, Pyocidin, Statrol, Terramycin w/ polymyxin, Terramycin w/ polymyxin b, Terramycin-polymyxin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
STATROLAlcon ResearchN-050344 DISCN1982-01-01
1 products
STATROLAlcon ResearchN-050456 DISCN1982-01-01
1 products
NEOSPORINGSKN-050176 DISCN1985-01-14
1 products
Hide discontinued
Bacitracin zinc
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
POLYSPORINGSKN-050167 DISCN1985-03-01
1 products
Hide discontinued
Dexamethasone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
MAXITROLHarrowN-050023 RX1982-01-01
1 products, RLD, RS
MAXITROLSandozN-050065 RX1982-01-01
1 products, RLD, RS
Neomycin sulfate
+
Polymyxin b sulfate
+
Prednisolone acetate
Tradename
Company
Number
Date
Products
POLY-PREDAllerganN-050081 DISCN1982-01-01
1 products
Hide discontinued
Polymyxin b sulfate
+
Trimethoprim sulfate
Tradename
Company
Number
Date
Products
POLYTRIMAllerganN-050567 DISCN1988-10-20
1 products, RLD
Hide discontinued
Chloramphenicol
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CHLOROMYXINPfizerN-050203 DISCN1982-01-01
1 products
Hide discontinued
Chloramphenicol
+
Hydrocortisone acetate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
OPHTHOCORTParkedale PharmaceuticalsN-050201 DISCN1982-01-01
1 products
Hide discontinued
Bacitracin zinc
+
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINCasper PharmaN-050416 DISCN1982-01-01
1 products, RLD
CORTISPORINMonarch PharmaceuticalsN-050168 DISCN1984-05-04
1 products, RLD
Hide discontinued
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CASPORYN HCCasper PharmaN-060613 RX1982-01-01
1 products, RLD, RS
Show 2 discontinued
Hydrocortisone acetate
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINMonarch PharmaceuticalsN-050218 DISCN1985-08-09
1 products, RLD
Hide discontinued
Bacitracin
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LANABIOTICCombeN-050598 DISCN1986-09-22
1 products
Hide discontinued
Bacitracin zinc
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LUMI-SPORYNCasper PharmaN-050417 RX1982-01-01
1 products, RLD
Oxytetracycline hydrochloride
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
TERRAMYCIN W/ POLYMYXIN B SULFATECasper PharmaN-061015 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
OTC monograph final2012-08-10
10 person ansiOTC monograph final2010-06-07
25 person ansiOTC monograph final2010-06-07
4314 first aid kit 4315 first aid kitunapproved drug other2019-05-10
50 person ansiOTC monograph final2010-06-07
acme first aid contains 404 piecesOTC monograph final2010-06-07
acme small cuts and burnsOTC monograph final2010-06-14
adventure first aid .5 tinOTC monograph not final2017-03-16
adventure medical kits 1-2 person first aidOTC monograph not final2011-01-11
adventure medical kits 1-2 person national ski patrol first aidOTC monograph not final2010-11-10
Show 309 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
wounds and injuries—D014947T14.8
gastrointestinal diseases—D005767—
pneumoniaEFO_0003106D011014—
bacterial infections—D001424A49
pseudomonas infectionsEFO_0001076D011552A41.52
bacterial skin diseases—D017192—
skin diseases—D012871L00-L99
escherichia coli infectionsEFO_1001318D004927B96.20
soft tissue infections—D018461—
streptococcal infectionsEFO_1001476D013290—
Show 89 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA05: Polymyxin b
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XB: Polymyxins
— J01XB02: Polymyxin b
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA18: Polymyxin b
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA11: Polymyxin b
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA03: Polymyxin b
HCPCS
No data
Clinical
No data
Drug
General
Drug common namePolymyxin b
INNpolymyxin b
Description
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. While it is useful for many Gram negative infections, it is not useful for Gram positive infections. It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled. The injectable form is generally only used if other options are not available. It is also available as the combinations bacitracin/polymyxin B and neomycin/polymyxin B/bacitracin for use on the skin.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O
Identifiers
PDB—
CAS-ID1405-20-5
RxCUI—
ChEMBL IDCHEMBL3989738
ChEBI ID—
PubChem CID4868
DrugBankDB00781
UNII IDJ2VZ07J96K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX7
Gene synonyms
NCBI Gene ID
5027
Protein name
P2X purinoceptor 7
Protein synonyms
ATP receptor, P2X7 receptor, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 7, purnergic receptor P2X 7
Uniprot ID
Q99572
Mouse ortholog
P2rx7 (18439)
P2X purinoceptor 7 (Q9Z1M0)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Polymyxin b
+
Bacitracin
+
Neomycin
Total medical expenditures per year (USD, in millions)
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Polymyxin b
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Bacitracin
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Polymyxin b
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Bacitracin
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Pramoxine
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Polymyxin b
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Dexamethasone
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Neomycin
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Polymyxin b
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Gramicidin
+
Neomycin
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Polymyxin b
+
Hydrocortisone
+
Neomycin
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Polymyxin b
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Hydrocortisone
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Polymyxin b
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Neomycin
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Pramoxine
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Polymyxin b
+
Prednisolone
+
Neomycin
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Polymyxin b
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Oxytetracycline
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Polymyxin b
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Trimethoprim
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Polymyxin b
Adverse Events
0 adverse events reported
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