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Drug ReportsPolymyxin b
Polymyxin b
Aerosporin, Casporyn, Chloromyxin, Cortisporin, Lanabiotic, Lumi-sporyn, Maxitrol, Mycitracin, Neo-polycin, Neosporin, Ocumycin, Ophthocort, Otobiotic, Poly-pred, Poly-rx, Polysporin, Polytrim, Pyocidin, Statrol (polymyxin b) is a protein pharmaceutical. Polymyxin b was first approved as Bacitracin-neomycin-polymyxin w/ hydrocortisone acetate on 1982-01-01. It is used to treat bacteremia, bacterial eye infections, bacterial infections, bacterial meningitis, and escherichia coli infections amongst others in the USA. It is known to target P2X purinoceptor 7.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Combinations
Casporyn, Lumi-sporyn, Maxitrol (generic drugs available since 1982-01-01, discontinued: Chloromyxin, Cortisporin, Dexacidin, Dexasporin, Lanabiotic, Mycitracin, Neo-polycin, Neosporin, Ocumycin, Ophthocort, Oticair, Otobione, Otobiotic, Otocort, Pediotic, Poly-pred, Polysporin, Polytrim, Pyocidin, Statrol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bacitracin
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LANABIOTICCombeN-050598 DISCN1986-09-22
1 products
Hide discontinued
Bacitracin zinc
+
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINCasper PharmaN-050416 DISCN1982-01-01
1 products, RLD
CORTISPORINMonarch PharmaceuticalsN-050168 DISCN1984-05-04
1 products, RLD
Hide discontinued
Bacitracin zinc
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
LUMI-SPORYNCasper PharmaN-050417 RX1982-01-01
1 products, RLD
Bacitracin zinc
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
POLYSPORINGSKN-050167 DISCN1985-03-01
1 products
Hide discontinued
Chloramphenicol
+
Hydrocortisone acetate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
OPHTHOCORTParkedale PharmaceuticalsN-050201 DISCN1982-01-01
1 products
Hide discontinued
Chloramphenicol
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CHLOROMYXINPfizerN-050203 DISCN1982-01-01
1 products
Hide discontinued
Dexamethasone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
MAXITROLHarrowN-050023 RX1982-01-01
1 products, RLD, RS
MAXITROLNovartisN-050065 RX1982-01-01
1 products, RLD, RS
Hydrocortisone
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CASPORYN HCCasper PharmaN-060613 RX1982-01-01
1 products, RLD, RS
Show 2 discontinued
Hydrocortisone acetate
+
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
CORTISPORINMonarch PharmaceuticalsN-050218 DISCN1985-08-09
1 products, RLD
Hide discontinued
Neomycin sulfate
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
STATROLAlcon ResearchN-050344 DISCN1982-01-01
1 products
STATROLAlcon ResearchN-050456 DISCN1982-01-01
1 products
NEOSPORINGSKN-050176 DISCN1985-01-14
1 products
Hide discontinued
Neomycin sulfate
+
Polymyxin b sulfate
+
Prednisolone acetate
Tradename
Company
Number
Date
Products
POLY-PREDAllerganN-050081 DISCN1982-01-01
1 products
Hide discontinued
Oxytetracycline hydrochloride
+
Polymyxin b sulfate
Tradename
Company
Number
Date
Products
TERRAMYCIN W/ POLYMYXIN B SULFATECasper PharmaN-061015 DISCN1982-01-01
1 products
Hide discontinued
Polymyxin b sulfate
+
Trimethoprim sulfate
Tradename
Company
Number
Date
Products
POLYTRIMAllerganN-050567 DISCN1988-10-20
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
10 person ansiOTC monograph final2010-06-07
25 person ansiOTC monograph final2010-06-07
4032 first aid kitunapproved drug other2024-01-22
4064 first aid kit 4065 first aid kit 4066 first aid kit 4067 first aid kitunapproved drug other2024-01-22
4125 first aid kit 4241 first aid kitunapproved drug other2024-01-22
4138 first aid kitunapproved drug other2024-01-22
4150 first aid kitunapproved drug other2024-01-22
4152 first aid kitunapproved drug other2024-01-22
4155 first aid kitunapproved drug other2024-01-22
4166 first aid kitunapproved drug other2024-01-22
Show 328 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacteremiaEFO_0003033D016470R78.81
bacterial eye infections—D015818—
bacterial infections—D001424A49
bacterial meningitisEFO_1000831D016920G00
escherichia coli infectionsEFO_1001318D004927B96.20
gastrointestinal diseases—D005767—
haemophilus infectionsEFO_1001127D006192—
klebsiella infectionsEFO_1001353D007710—
otitis externaEFO_0009560D010032H60
pseudomonas infectionsEFO_0001076D011552—
Show 4 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA05: Polymyxin b
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XB: Polymyxins
— J01XB02: Polymyxin b
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA18: Polymyxin b
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA11: Polymyxin b
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA03: Polymyxin b
HCPCS
No data
Clinical
Clinical Trials
175 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Castration-resistant prostatic neoplasmsD064129——61161120
SepsisD018805HP_0100806A41.9—12169
Septic shockD012772—A48.3——1179
Dental pulp necrosisD003790—K04.13——227
Periapical periodontitisD010485EFO_1001391K04.51——124
Gram-negative bacterial infectionsD016905————12—3
Periapical abscessD010482EFO_1001202——11113
Surgical wound infectionD013530—————2—2
Drug-related side effects and adverse reactionsD064420—T88.7—1—1—2
Urinary tract infectionsD014552EFO_0003103N39.0———112
Show 13 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471—C612122—117
Ventilator-associated pneumoniaD053717EFO_1001865J95.851—22—25
InfectionsD007239EFO_0000544—112—14
BurnsD002056—T30.0231—14
BacteremiaD016470EFO_0003033R78.81—12——2
Critical illnessD016638————1—12
PeritonitisD010538EFO_0008588K65——1—12
Iatrogenic diseaseD007049————1——1
Healthcare-associated pneumoniaD000077299———11——1
Bacterial conjunctivitisD003234EFO_1000829H10.0——1——1
Show 8 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5011——34
Coronary stenosisD023921EFO_1000882——1——23
NeoplasmsD009369—C8022———2
Colorectal neoplasmsD015179——12———2
Ovarian neoplasmsD010051EFO_0003893C5612———2
AdenocarcinomaD000230———2———2
Neoadjuvant therapyD020360———2———2
Myeloid leukemia acuteD015470—C92.011———1
Triple negative breast neoplasmsD064726——11———1
Small cell lung carcinomaD055752——11———1
Show 10 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382—U07.11———12
OsteomyelitisD010019EFO_0003102M861————1
RetinoblastomaD012175——1————1
Healthy volunteers/patients———1————1
Asymptomatic diseasesD058070——1————1
Lacrimal duct obstructionD007767——1————1
Intractable painD010148——1————1
RegenerationD012038——1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EndotoxemiaD019446——————55
Respiratory tract infectionsD012141—J06.9————22
PneumoniaD011014EFO_0003106—————22
Pancreatic cystD010181HP_0001737K86.2————22
Diabetes mellitusD003920HP_0000819E08-E13————11
Periapical diseasesD010483EFO_0010688—————11
Cystic fibrosisD003550EFO_0000390E84————11
Corneal diseasesD003316—H18.9————11
PterygiumD011625—H11.0————11
PancreatitisD010195HP_0001733K85————11
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePolymyxin b
INNpolymyxin b
Description
Polymyxin B, sold under the brand name Poly-Rx among others, is an antibiotic used to treat meningitis, pneumonia, sepsis, and urinary tract infections. While it is useful for many Gram negative infections, it is not useful for Gram positive infections. It can be given by injection into a vein, muscle, or cerebrospinal fluid or inhaled. The injectable form is generally only used if other options are not available. It is also available as the combinations bacitracin/polymyxin B and neomycin/polymyxin B/bacitracin for use on the skin.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O.CC[C@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H](C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCN)NC1=O)[C@@H](C)O
Identifiers
PDB—
CAS-ID1405-20-5
RxCUI—
ChEMBL IDCHEMBL3989738
ChEBI ID—
PubChem CID4868
DrugBankDB00781
UNII IDJ2VZ07J96K (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RX7
P2RX7
Organism
Homo sapiens
Gene name
P2RX7
Gene synonyms
NCBI Gene ID
5027
Protein name
P2X purinoceptor 7
Protein synonyms
ATP receptor, P2X7 receptor, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand gated ion channel, 7, purnergic receptor P2X 7
Uniprot ID
Q99572
Mouse ortholog
P2rx7 (18439)
P2X purinoceptor 7 (Q9Z1M0)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Polymyxin b
+
Bacitracin
+
Neomycin
Total medical expenditures per year (USD, in millions)
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Polymyxin b
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Bacitracin
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Polymyxin b
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Bacitracin
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Pramoxine
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Polymyxin b
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Dexamethasone
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Neomycin
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Polymyxin b
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Gramicidin
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Neomycin
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Polymyxin b
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Hydrocortisone
+
Neomycin
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Polymyxin b
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Hydrocortisone
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Polymyxin b
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Neomycin
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Pramoxine
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Polymyxin b
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Prednisolone
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Neomycin
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Polymyxin b
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Oxytetracycline
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Polymyxin b
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Trimethoprim
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 25,194 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,335 adverse events reported
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